Academic Staff - Dr Derek Macmillan - Organic/ Chemical Biology

Organic Synthesis Carbohydrate and glycopeptide chemistry Peptide and protein synthesis Engineering and directed evolution of proteins

Biographical details tel: +44 (0)20 7679 4684 fax: +44 (0)20 7679 7463 internal: 24684 email: d.macmillan@ucl.ac.uk Macmillan group website

Our work is in two main areas: a) organic synthesis with a particular emphasis on carbohydrate and glycopeptide chemistry b) synthesis, semi-synthesis and engineering of peptides, proteins and enzymes.

Selected publications

1. Bloom, J.D., Meinhold, P. Meyer, M.M., Otey, C.R., Macmillan, D. & Arnold, F.H. Evolving Strategies for Enzyme Engineering, 2005 , Curr. Opin Struct. Biol, 15, 447-452.
2. Macmillan, D. & Anderson D.W. Rapid synthesis of Acyltransfer Auxiliaries for Cysteine-free Native Glycopetide Ligation. 2004 , Org. Lett. 6(25), 4659-4662.
3. Macmillan, D. & Arham, L. Cyanogen Bromide Cleavage Generates Fragments Suitable for Expressed Protein and Glycoprotein Ligation. 2004 , J. Am. Chem. Soc. 124, 9530-9531.
4. Macmillan, D. & Bertozzi, C. R. Modular Assembly of Glycoproteins: Towards the Synthesis of GlyCAM-1 by using Expressed Protein Ligation. 2004 , Angew. Chem. Int. Ed. 43, 1355-1359.
5. Macmillan, D., Daines, A. M., Bayrhuber, M. & Flitsch, S. L. Solid-Phase Synthesis of Thioether-Linked Glycopeptide Mimics for Application to Glycoprotein Semisynthesis. 2002 , Org. Lett. 4, 1467-1470.
6. Macmillan, D., Bill, R. M., Sage, K. A., Fern, D. & Flitsch, S. L. Selective in vitro glycosylation of recombinant proteins: semi-synthesis of novel homogeneous glycoforms of human erythropoietin. 2001 , Chem. Biol. 8, 133-145.
7. Macmillan, D. & Bertozzi, C. R. New directions in glycoprotein engineering. 2000 , Tetrahedron 56, 9515-9525.

This page last modified 20 October, 2009